After protein folding powered by Meta and DeepMind, the next challenge is to accurately predict epistasis

9 November 2022

Epistasis dramatically influences the success of drug discovery projects: The real lead drug candidate is missed if epistasis is not taken into account.

After protein folding powered by Meta and DeepMind , the next challenge is to accurately predict epistasis ie. the impact of non-linear interactions of mutations within the protein sequence. PEACCEL’s founder, co-authored in ACS Catalysis a critical review on epistasis with its partners at Leibniz Institute of Plant Biochemistry.

Read more: https://pubs.acs.org/doi/10.1021/acscatal.2c01426#

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